ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
Latest Newsletters
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
Latest Government Action
R&D Insight
Can you help?
Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
Summaries
Developing systemic & inhaled antibiotics for lung infections
Assessing antibiotic value: DTR, fire extinguishers, and a view from Australia
FDA Workshop: Animal Models To Support Antibacterial Development (5 Mar 2020, post-meeting notes)
New mechanisms for antibiotic reimbursement in the United States: CMS’s IPPS FY2020 Final Rule
IDSA White Paper on developing narrow-spectrum antimicrobials + editorial by G. Drusano
In Praise of Non-Inferiority
FDA analysis of 40-years of antibacterial development: Dheman et al.
Plazomicin EU marketing application is withdrawn: Near zero market value of newly approved antibacterials
Lessons in Discovery from Lynn Silver + Pro-con on alternatives to antibiotics
Public meeting on the LPAD Pathway: Post-meeting thoughts (wonkish)
Modeling the value of an effective antibiotic — Megiddo et al.
The hunt for oral antibiotics: Beyond Lipinski’s Rule of Five
Have you used a fire extinguisher today? Are you using one now?
Even when there isn’t a fire, you’re using a fire extinguisher. You bought it, you stored it, and you know it will work.
Antibiotics are to infections as fire extinguishers are to fires.
Fire fighters know their tools will put out the biggest of flames but the same cannot be said for physicians.
Antibiotics provide a safety net for all of health care. This safety net is beginning to fall apart because of issues like superbugs, failing agent development pipelines, and problematic economic models.
The fire department isn't paid per fire.
You don't buy a fire extinguisher as the fire is breaking out.
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet
I did not invent penicillin. Nature did that. I only discovered it by accident.
Alexander Fleming Tweet